Research Directions

Research Overview

Our research focuses on bio and biomimetic catalysis, with particular emphasis on the high-value utilization of lignin and the development of covalent organic framework (COF) artificial enzymes. We are committed to advancing sustainable biomanufacturing through innovative catalytic systems and process optimization.

High-value Utilization of Lignin

Developing efficient catalytic processes for converting lignin into valuable chemicals and materials, contributing to sustainable biomass utilization.

Bio and Biomimetic Catalysis

Designing and synthesizing artificial enzymes based on covalent organic frameworks (COFs) for enhanced catalytic performance and stability.

Lignin Valorization

Developing innovative approaches for lignin depolymerization and conversion into high-value products including aromatic chemicals, polymers, and advanced materials.

Lignin Depolymerization Aromatic Chemicals Bio-based Polymers

COF Artificial Enzymes

Designing and synthesizing covalent organic framework-based artificial enzymes with enhanced catalytic activity, selectivity, and stability for various biotransformations.

COF Synthesis Enzyme Mimetics Biocatalysis

Enzyme Immobilization

Developing advanced immobilization strategies using COF materials to enhance enzyme stability, reusability, and performance in industrial applications.

Enzyme Immobilization COF Supports Industrial Biocatalysis

Sustainable Processes

Developing environmentally friendly and economically viable processes for biomass conversion and chemical production with minimal environmental impact.

Green Chemistry Process Optimization Sustainability

Research Achievements

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Representative Publications

High-Efficiency Dual-Site Biomimetic Catalyst for Lignin Depolymerization (JIANG Wenzhi)

ACS Catalysis, 2025, 15 (3), 2595-2606

Boosting Catalytic Performance of Cytochrome c through Tailored Carboxymethylation in Covalent Organic Frameworks(SHI Lunlun)

ACS Catalysis, 2024, 14 (10), 7639-7648

In Situ Encapsulation of Cytochrome c within Covalent Organic Framesworks Using Deep Eutectic Solvents under Ambient Conditions(LI Liangwei)

ACS Applied Materials & Interfaces, 2023, 15 (46), 53871-53880

Anchoring Effect-Induced Conformation Remodeling in Epoxy-Functionalized Covalent Organic Frameworks for Enhanced Enzymatic Efficiency(LU Yikang)

Langmuir, 2025, 41, 18, 11765–11775

Harnessing Copper-Metalated Covalent Organic Frameworks: A Biomimetic Approach to High-Efficiency Dye Degradation(ZHAN Jiamin)

ACS Applied Engineering Materials, 2024, 3 (1), 225-232

Chlorine Axial Coordination Enables Peroxidase Mimicking and Lignin Depolymerization in Fe–N3O Single-Atom Nanozymes(LI Qifeng)

ACS Applied Materials & Interfaces, 2025, 17 (30), 43378–43389

Patents

Immobilized Enzyme Catalyst Based on Epoxy-Modified Covalent Organic Framework Carrier and Preparation Method Thereof

Chinese Invention Patent, Application No.: CN202411320749.4

Immobilized Enzyme Catalyst Based on Carboxyl-Modified Covalent Organic Framework Carrier and Preparation Method Thereof

Chinese Invention Patent, Application No.: CN202310666094.5

Preparation Method of Artificial Dual-Site Biomimetic Multi-Enzyme Catalyst and Its Application in Lignin Degradation

Chinese Invention Patent, Application No.: CN202411239367.9

Research Projects

Design and Construction of Artificial Enzymes Based on Covalent Organic Frameworks

Guangdong Natural Science Foundation General Project, Principal Investigator, 2025-2027

Design, Construction and Mechanism Study of Enzyme-Chemical Synergistic Catalytic Systems

National Natural Science Foundation Youth Project, Principal Investigator, Completed

Construction and Regulation Mechanism of Artificial Carrier Multi-Enzyme Assembly Systems

National Key R&D Program, Participant, Completed