Research Directions
Lignin Utilization
Lignin, as the only naturally renewable aromatic polymer reservoir in nature, is a key building block for constructing sustainable chemicals and advanced functional materials as an alternative to fossil resources. However, its highly complex heterogeneous structure and inherent recalcitrance constitute natural barriers to its efficient depolymerization and directional conversion. Existing thermochemical depolymerization strategies often fall into a trade-off dilemma between "reactivity and selectivity": the harsh conditions required to activate inert chemical bonds often induce uncontrolled condensation of highly reactive intermediates or destruction of aromatic structures, a bottleneck that severely restricts the progress of high-value utilization of lignin resources.
Green Catalysis
In response to the above challenges, this research draws on the catalytic wisdom of biological enzymes' "mild oxidation-precise cleavage" and is committed to developing a new biomimetic catalysis paradigm based on covalent organic frameworks (COFs). Leveraging the atomic-level precise topological structure design, regular nanopores, and excellent physicochemical stability of COF materials, this research aims to artificially construct enzyme-like active centers and reconstruct their unique catalytic microenvironment. This strategy seeks to achieve specific activation and directional cleavage of inert C-O/C-C bonds in lignin under mild conditions through precise regulation of the electronic structure and spatial confinement effects of active sites, providing systematic scientific solutions for breaking through the kinetic bottleneck of biomass conversion.
Research Achievements
Google ScholarRepresentative Publications
High-Efficiency Dual-Site Biomimetic Catalyst for Lignin Depolymerization (JIANG Wenzhi)
ACS Catalysis, 2025, 15 (3), 2595-2606
Boosting Catalytic Performance of Cytochrome c through Tailored Carboxymethylation in Covalent Organic Frameworks(SHI Lunlun)
ACS Catalysis, 2024, 14 (10), 7639-7648
In Situ Encapsulation of Cytochrome c within Covalent Organic Framesworks Using Deep Eutectic Solvents under Ambient Conditions(LI Liangwei)
ACS Applied Materials & Interfaces, 2023, 15 (46), 53871-53880
Anchoring Effect-Induced Conformation Remodeling in Epoxy-Functionalized Covalent Organic Frameworks for Enhanced Enzymatic Efficiency(LU Yikang)
Langmuir, 2025, 41, 18, 11765–11775
Harnessing Copper-Metalated Covalent Organic Frameworks: A Biomimetic Approach to High-Efficiency Dye Degradation(ZHAN Jiamin)
ACS Applied Engineering Materials, 2024, 3 (1), 225-232
Chlorine Axial Coordination Enables Peroxidase Mimicking and Lignin Depolymerization in Fe–N3O Single-Atom Nanozymes (LI Qifeng)
ACS Applied Materials & Interfaces, 2025, 17 (30), 43378–43389
Biomimetic Dual-Coordination-Sphere Porphyrin-Based Covalent Organic Frameworks Enable Efficient and Selective Furfural Oxidation (ZHAN Jiamin)
ACS Applied Materials & Interfaces, 2025, 17 (36), 51043–51052
Laccase-Inspired Single-Atom Fe–N4 Nanozymes for Pollutant Degradation and Lignin Valorization (MA Yingjin)
Langmuir, 2025, 41, 48, 32876–32884
Patents
Immobilized Enzyme Catalyst Based on Epoxy-Modified Covalent Organic Framework Carrier and Preparation Method Thereof
Chinese Invention Patent, Application No.: CN202411320749.4
Immobilized Enzyme Catalyst Based on Carboxyl-Modified Covalent Organic Framework Carrier and Preparation Method Thereof
Chinese Invention Patent, Application No.: CN202310666094.5
Preparation Method of Artificial Dual-Site Biomimetic Multi-Enzyme Catalyst and Its Application in Lignin Degradation
Chinese Invention Patent, Application No.: CN202411239367.9
Research Projects
Design and Construction of Artificial Enzymes Based on Covalent Organic Frameworks
Guangdong Natural Science Foundation General Project, Principal Investigator, 2025-2027
Design, Construction and Mechanism Study of Enzyme-Chemical Synergistic Catalytic Systems
National Natural Science Foundation Youth Project, Principal Investigator, Completed
Construction and Regulation Mechanism of Artificial Carrier Multi-Enzyme Assembly Systems
National Key R&D Program, Participant, Completed