科研方向
木质素高值化利用
木质素是自然界储量最为丰富的可再生芳香族高分子，其骨架富含芳环结构与多样含氧官能团，是替代化石资源、构筑高性能功能材料的重要平台分子。然而，木质素结构高度无序、化学键能差异显著且抗降解性强，致使其高效定向转化长期面临挑战。本人研究以木质素高值化利用为统一主线，将"解聚—改造—成材"贯通为一个有机整体：以目标功能材料为牵引，对木质素实施可控解聚与定向改造，进而构筑系列高附加值功能材料。围绕这一主线，研究工作于以下两个层面递进展开。
一、木质素的解聚与改造
木质素的高效利用，首先取决于对其大分子骨架的可控解聚与定向改造。研究聚焦惰性化学键活化与高活性中间体易缩合之间的固有矛盾，发展温和、绿色的选择性解聚与氧化体系，将木质素定向转化为结构明晰的芳香单体与平台化合物；并辅以接枝、共聚、磺化、胺化及酚羟基调控等手段对其进行结构修饰，精准调节反应活性、溶解性与界面行为，为下游功能材料提供结构可控、性能可调的分子基元。为实现上述温和而高选择性的转化，研究中以共价有机框架（COFs）、单原子纳米酶等为平台，师法天然木质素降解酶（漆酶、过氧化物酶）构筑类酶催化体系，作为支撑解聚与改造的关键工具。
二、木质素基功能材料
承接上述解聚与改造所得的分子基元，以改造后的木质素为平台分子，面向能源、环境、生物医用与绿色化工等领域的重大需求，构筑系列高值化功能材料；而材料的性能需求亦反向牵引并定义上游的解聚与改造路线，由此形成"应用牵引—解聚改造—材料落地"的闭环研究范式：
- 树脂与胶黏材料：构筑木质素基酚醛/环氧树脂及胶黏剂，部分替代石油基原料，提升体系的绿色属性与综合性能。
- 抗菌材料：发挥木质素富酚羟基与天然抗氧化特性，构建抗菌复合材料、涂层与功能薄膜。
- 光热材料：发展木质素基光热转换材料，应用于太阳能界面蒸发、光热抑菌与防伪等场景。
- 碳材料：以木质素为碳前驱体衍生多孔碳、碳纤维等，服务于储能、吸附与催化载体等方向。
学术论文
科研之友第一作者 / 通讯作者论文，按发表时间由近及远排序（共 29 篇）
Laccase-Inspired Single-Atom Fe-N4 Nanozymes for Pollutant Degradation and Lignin Valorization
Ma, Yingjin; Li, Qifeng; Qiu, Xueqing; Li, Zhixian*
Langmuir, 2025, 41(48): 32876-32884通讯作者
Biomimetic Dual-Coordination-Sphere Porphyrin-Based Covalent Organic Frameworks Enable Efficient and Selective Furfural Oxidation
Zhan, Jiamin; Wu, Xiaoling; Qiu, Xueqing; Li, Zhixian*
ACS Applied Materials & Interfaces, 2025, 17(36): 51043-51052通讯作者
Chlorine Axial Coordination Enables Peroxidase Mimicking and Lignin Depolymerization in Fe-N3O Single-Atom Nanozymes
Li, Qifeng; Jiang, Wenzhi; Wu, Xiaoling; Lou, Hongming; Qiu, Xueqing; Li, Zhixian*
ACS Applied Materials & Interfaces, 2025, 17(30): 43378-43389通讯作者
Anchoring Effect-Induced Conformation Remodeling in Epoxy-Functionalized Covalent Organic Frameworks for Enhanced Enzymatic Efficiency
Lu, Yikang; Wu, Xiaoling; Lou, Hongming*; Li, Zhixian*
Langmuir, 2025, 41(18): 11765-11775共同通讯作者
High-Efficiency Dual-Site Biomimetic Catalyst for Lignin Depolymerization
Jiang, Wenzhi; Li, Qifeng; Cao, Meifang; Lou, Hongming; Li, Zhixian*; Qiu, Xueqing*
ACS Catalysis, 2025, 15(3): 2595-2606共同通讯作者
Harnessing Copper-Metalated Covalent Organic Frameworks: A Biomimetic Approach to High-Efficiency Dye Degradation
Zhan, Jiamin; Li, Liangwei; Ma, Yingjin; Lou, Hongming; Li, Zhixian*
ACS Applied Engineering Materials, 2025, 3(1): 225-232通讯作者
Boosting Catalytic Performance of Cytochrome c through Tailored Carboxymethylation in Covalent Organic Frameworks
Shi, Lunlun; Chen, Xiupeng; Li, Aitao; Wu, Xiaoling; Kong, Xian*; Lou, Hongming; Li, Zhixian*
ACS Catalysis, 2024, 14(10): 7639-7648共同通讯作者
Enhanced solar interfacial evaporation through lignin-polyaniline composite coatings on Balsa wood substrates
Lu, Haosheng; Li, Qifeng; Liu, Weifeng; Li, Zhixian*
International Journal of Biological Macromolecules, 2024, 281: 136382通讯作者
Ultrasonic-assisted synthesis of lignin-based ultrasmall silver nanoparticles for photothermal-mediated sterilization
Jiang, Wenzhi; Zhang, Yingchun; Yang, Dongjie; Qiu, Xueqing; Li, Zhixian*
International Journal of Biological Macromolecules, 2024, 262: 129827通讯作者
In Situ Encapsulation of Cytochrome c within Covalent Organic Frames Using Deep Eutectic Solvents under Ambient Conditions
Li, Liangwei; Wu, Xiaoling; Pang, Yuxia; Lou, Hongming; Li, Zhixian*
ACS Applied Materials & Interfaces, 2023, 15(46): 53871-53880通讯作者
Fabrication of tobacco-stem-derived hierarchical porous carbon via synergistic gas exfoliation effect for high-performance supercapacitors
Tan, Haicheng; Fan, Yukang; Pan, Xiaowei; Chen, Senlin*; Tao, Hong; Yang, Dongjie; Zhang, Wenli; Li, Zhixian*
Industrial Crops and Products, 2023, 191: 115981共同通讯作者
Fabrication of a Highly Efficient Wood-Based Solar Interfacial Evaporator with Self-Desalting and Sterilization Performance
Yan, Caihua; Huang, Jinhao; Liang, Zicong; Fang, Zhiqiang; Yang, Dongjie; Li, Zhixian*
Langmuir, 2022, 38(42): 12813-12821通讯作者
UV-Assisted Room-Temperature Fabrication of Lignin-Based Nanosilver Complexes for Photothermal-Mediated Sterilization
Zhang, Yingchun; Yang, Dongjie*; Qiu, Xueqing; Li, Zhixian*
ACS Applied Bio Materials, 2022, 5(12): 5943-5952共同通讯作者
Engineering of Near-Infrared-Activated Lignin-Polydopamine-Nanosilver Composites for Highly Efficient Sterilization
Zhang, Yingchun; Wang, Yalin; Li, Zhixian*; Yang, Dongjie*; Qiu, Xueqing
ACS Applied Bio Materials, 2022, 5(9): 4256-4263共同通讯作者
Fabrication of a Lignin-Copper Sulfide-Incorporated PVA Hydrogel with Near-Infrared-Activated Photothermal/Photodynamic/Peroxidase-like Performance for Combating Bacteria and Biofilms
Xie, Yuanxiang; Gan, Chuchu; Li, Zhixian*; Liu, Weifeng; Yang, Dongjie*; Qiu, Xueqing
ACS Biomaterials Science & Engineering, 2022, 8(2): 560-569共同通讯作者
Near-Infrared-Activated Efficient Bacteria-Killing by Lignin-Based Copper Sulfide Nanocomposites with an Enhanced Photothermal Effect and Peroxidase-like Activity
Xie, Yuanxiang; Qian, Yong; Li, Zhixian*; Liang, Zicong; Liu, Weifeng; Yang, Dongjie*; Qiu, Xueqing
ACS Sustainable Chemistry & Engineering, 2021, 9(18): 6479-6488共同通讯作者
Fabrication of litchi-like lignin/zinc oxide composites with enhanced antibacterial activity and their application in polyurethane films
Wang, Yuanyuan; Wang, Huan; Li, Zhixian*; Yang, Dongjie*; Qiu, Xueqing; Liu, Yechen; Yan, Mengzhen; Li, Qiong
Journal of Colloid and Interface Science, 2021, 594: 316-325共同通讯作者
Microwave-mediated fabrication of silver nanoparticles incorporated lignin-based composites with enhanced antibacterial activity via electrostatic capture effect
Wang, Yalin; Li, Zhixian*; Yang, Dongjie*; Qiu, Xueqing; Xie, Yuanxiang; Zhang, Xing
Journal of Colloid and Interface Science, 2021, 583: 80-88共同通讯作者
Model Compounds Study for the Mechanism of Horseradish Peroxidase-Catalyzed Lignin Modification
Yang, Dongjie; Wang, Yalin; Huang, Wenjing; Li, Zhixian*; Qiu, Xueqing*
Applied Biochemistry and Biotechnology, 2020, 191(3): 981-995共同通讯作者
Biomimetic metal-organic frameworks mediated hybrid multi-enzyme mimic for tandem catalysis
Zhong, Xue; Xia, Huan; Huang, Wenquan; Li, Zhixian*; Jiang, Yanbin*
Chemical Engineering Journal, 2020, 381: 122758共同通讯作者
HKUST-1 catalyzed efficient in situ regeneration of NAD+ for dehydrogenase mediated oxidation
Xia, Huan; Li, Zhixian; Zhong, Xue; Li, Binghui; Jiang, Yunpeng; Jiang, Yanbin*
Chemical Engineering Science, 2019, 203: 43-53共同第一作者
Palladium-mediated hybrid biocatalysts with enhanced enzymatic catalytic performance via allosteric effects
Xia, Huan; Zhong, Xue; Li, Zhixian*; Jiang, Yanbin
Journal of Colloid and Interface Science, 2019, 533: 1-8通讯作者
Folate-conjugated zein/Fe3O4 nanocomplexes for the enhancement of cellular uptake and cytotoxicity of gefitinib
Pang, Jiafeng; Li, Zhixian*; Li, Shaomin; Lin, Shuying; Wang, Hongdi; Xie, Qiuling*; Jiang, Yanbin
Journal of Materials Science, 2018, 53(21): 14907-14921共同通讯作者
Polydopamine-Mediated Carrier with Stabilizing and Self-Antioxidative Properties for Polyphenol Delivery Systems
Li, Shaomin; Li, Zhixian*; Pang, Jiafeng; Chen, Jing; Wang, Hongdi; Xie, Qiuling; Jiang, Yanbin*
Industrial & Engineering Chemistry Research, 2018, 57(2): 590-599共同通讯作者
In situ hybridization of enzymes and their metal-organic framework analogues with enhanced activity and stability by biomimetic mineralisation
Li, Zhixian; Xia, Huan; Li, Shaomin; Pang, Jiafeng; Zhu, Wei; Jiang, Yanbin*
Nanoscale, 2017, 9(40): 15298-15302第一作者
Highly active, stable and self-antimicrobial enzyme catalysts prepared by biomimetic mineralization of copper hydroxysulfate
Li, Zhixian; Ding, Yi; Li, Shaomin; Jiang, Yanbin*; Liu, Zheng; Ge, Jun*
Nanoscale, 2016, 8(40): 17440-17445第一作者
An enzyme-copper nanoparticle hybrid catalyst prepared from disassembly of an enzyme-inorganic nanocrystal three-dimensional nanostructure
Li, Zhixian; Ding, Yi; Wu, Xiaoling; Ge, Jun*; Ouyang, Pingkai; Liu, Zheng
RSC Advances, 2016, 6(25): 20772-20776共同第一作者
Spatial co-localization of multi-enzymes by inorganic nanocrystal-protein complexes
Li, Zhixian; Zhang, Yifei; Su, Yechao; Ouyang, Pingkai; Ge, Jun*; Liu, Zheng*
Chem. Commun., 2014, 50(83): 12465-12468第一作者
Lipase-Catalyzed One-Step and Regioselective Synthesis of Clindamycin Palmitate
Li, Zhixian; Zhang, Yifei; Lin, Mengmeng; Ouyang, Pingkai; Ge, Jun*; Liu, Zheng*
Organic Process Research & Development, 2013, 17(9): 1179-1182第一作者